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In patients with atrial fibrillation who were unable to receive warfarin for any reason, the use of apixaban reduced the risk of stroke and systemic embolism when compared to aspirin. Study Rundown: Atrial fibrillation is a common arrhythmia that increases the risk of stroke and. AVERROES has shown that the new oral anti-Xa inhibitor apixaban is superior to aspirin in terms of efficacy, with surprisingly similar safety. AVERROES. Apixaban Versus ASA. To Reduce the Risk Of Stroke. Coordinated by Population Health Research institute. Hamilton, Ontario, Canada. Sponsors.

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Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: Read your latest personalised notifications Sign in No account yet?

AVERROES – Wiki Journal Club

The New England Journal of Medicine. Patients were eligible if they were 50 years of age or older and if they had atrial fibrillation that had been documented in the 6 averries prior to enrollment or by lead electrocardiography on the day of screening. Strengths Strong points and important messages of the study are: In addition, patients could not averros receiving VKA therapy, either because it had been demonstrated unsuitable in their case or because it was expected to be unsuitable.

Apixaban is a novel oral anticoagulant that inhibits factor Xa. There were 44 1. Effect of clopidogrel added to aspirin in patients with atrial fibrillation. Patients also needed to have at least one of the following risk factors for stroke: Statistics presented where given by the authors. Hospitalized patients with atrial fibrillation and a high risk of stroke are not being provided with adequate anticoagulation. Dabigatran versus warfarin in patients with atrial fibrillation.


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In patients with atrial fibrillation thought to be unsuitable for anticoagulation with a vitamin K antagonist, does apixaban reduce risk for stroke or systemic embolism when compared to aspirin?

There appixaban 11 intracranial bleeds on apixaban and 13 on aspirin apixaban 1. To reduce the burden of cardiovascular disease. The trial was terminated early given a treatment benefit averrooes apixaban.

Yet, these proportions reflect the current underuse of VKAs in multiple registries. Guidelines for the management of atrial fibrillation: Concurrent medications whose metabolism could be affected by VKAs; 9. Views Read View source View history.

The AVERROES Trial – Clinical Implications

There were 51 primary outcome events in those randomised to apixaban 1. Also, how does apixaban compare to aspirin apixabxn of major bleeding? Usable articles Cardiology Neurology. This proportion was similar for both averrkes and community hospitals. The reasons that VKA therapy was unsuitable for the patient had to be documented in the study case report forms. Its role in prevention of stroke in patients unsuitable for VKA therapy, but maintained on aspirin therapy, was unknown.

Assessment that INR could not or was unlikely to be measured at requested interval; 5. Retrieved from ” http: Sign in to My ESC.

Connolly SJ, et al. Concurrent medications that could alter activity of VKAs; 8.

ESC sub specialties communities. Assessment that patient would be unable or unlikely to adhere to restrictions on factors such as alcohol and diet; All these reasons can be grouped in three broad categories: To get the best experience using our website we recommend that you upgrade to a newer version.


AVERROES on the other hand has shown that the new oral anti-Xa inhibitor apixaban is superior to aspirin in terms of efficacy, with surprisingly similar safety.

J Am Coll Cardiol ; Apixaban in Patients with Atrial Fibrillation. Dual therapy decreased rates of major vascular events at cost of increased major bleeding. Based on the indirect comparison with ACTIVE A, one should conclude that apixaban is, at the time of writing, the best alternative to aspirin ever found in patients deemed unsuitable for VKAs.

Presented as apixaban vs.

The median duration of follow-up was 1. We will here briefly discuss the clinical implications of the trial. Don’t miss out Read your latest personalised notifications Ok, got it. Navigation menu Personal tools Create account Log in.

Notes to editor Correspondence: In April the Data and Safety Monitoring Board recommended early study termination because of clear benefit in favor of apixaban. Of the patients enrolled, reasons for being deemed unsuitable for VKA therapy included the following: In such patients, aspirin plus clopidogrel reduced the rate of major vascular events, in particular stroke, vs.

Expected difficulty in contacting patient for urgent change in dose avrroes VKAs; 6.